Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia
نویسندگان
چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولFrequent promoter methylation of CDH1 in non-neoplastic mucosa of sporadic diffuse gastric cancer.
BACKGROUND/AIM To identify promoter methylation as a major silencing mechanism in potential precursor lesions of sporadic diffuse gastric cancer (DGC), we investigated promoter methylation of CDH1 (E-Cadherin gene) in a series of DGCs and matched normal mucosa. MATERIALS AND METHODS The extent of CDH1 gene promoter methylation was explored using methylation-specific polymerase chain reaction ...
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متن کاملAberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas.
Recent studies have shown that promoter hypermethylation of tumor suppressor genes is an important factor in carcinogenesis of several human organs. The purpose of this study was to examine the methylation status of CHFR, a novel cell cycle regulatory gene, in both primary oral cancer tumors and the adjacent normal mucosa, and to clarify the relation between the methylation status and expressio...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2004
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6601849